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Can Lisinopril 40 Mg Be Cut in Half

doi: 10.17305/bjbms.2007.3022.

Influence of tablet splitting on content uniformity of lisinopril/hydrochlorthiazide tablets

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  • PMID: 18039191
  • PMCID: PMC5728606
  • DOI: 10.17305/bjbms.2007.3022

Free PMC article

Influence of tablet splitting on content uniformity of lisinopril/hydrochlorthiazide tablets

Edina Vranić  et al. Bosn J Basic Med Sci. 2007 Nov .

Free PMC article

Abstruse

Dose-related agin furnishings of medications are a major problem in modern medical do. The "right" dose, based on drug company guidelines in package inserts, may not exist correct for many patients. Tablet splitting or dividing has been an accepted practice for many years every bit a means of obtaining the prescribed dose of medication. As model tablets for this investigation, two batches of lisinopril- hydrochlorothiazide scored tablets labeled to incorporate xx/12.5 mg were used. The aim of this study was to establish possible influence of tablet splitting on content uniformity of lisinopril/hydrochlorthiazide tablets. Decision of the content uniformity of lisinopril and hydrochlorthiazide in our batches, was carried out past HPLC method. The results of content uniformity studies for halves of tablets containing combination of lisinopril-hydrochlorthiazide (supposed to contain fifty% of stated 20/12.5 mg in the whole tablet) were: 49.lx +/-iii.29% and 49.29+/-0.60 % (lisinopril); 50.33+/-iii.50% and 50.69+/-1.95% (hydrochlorthiazide) for batch I and II, respectively. We tin conclude that the results obtained in this study back up an option of tablet splitting, which is very important for obtaining the required dosage when a dosage form of the required force is unavailable, and for better individualization of the therapy.

Figures

FIGURE 1
FIGURE one

Manual method performed for breaking tablets

FIGURE 2
Effigy 2

Tablet splitter

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Source: https://pubmed.ncbi.nlm.nih.gov/18039191/